What is Durolane?
Durolane est une injection intra-articulaire d'acide hyaluronique pur (60 mg dans 3,0 mL, soit 20 mg/mL), stabilisée par la technologie NASHA®. Une seule injection par cycle restaure la viscosité du liquide synovial ; sa demi-vie dans le genou est d'environ 32 jours. Elle ne contient aucun stéroïde.
How Durolane works
Durolane restores the viscoelasticity of synovial fluid depleted by osteoarthritis. The 60 mg of hyaluronic acid (20 mg/mL) are stabilized by NASHA® technology, which keeps cross-linking low while slowing enzymatic breakdown. The result is a joint half-life of about 32 days from a single injection, with no corticosteroid.
Who it is for
Durolane suits people with osteoarthritis of the knee, hip or another synovial joint who want a steroid-free hyaluronic acid treatment in a single session. It is a relevant option when a corticosteroid is not advised, for example with poorly controlled diabetes.
When to avoid Durolane
- Infection or active inflammation in the target joint
- Infection or skin disease at the injection site
- Known allergy to hyaluronic acid preparations
- Large joint effusion: drain before injecting
- Pregnancy, breastfeeding and children: safety not established
Technical sheet
| Fabricant | Bioventus |
|---|---|
| Volume de la seringue | 3,0 mL, verre, préremplie (Luer-lok) |
| Ingrédient actif | Hyaluronate de sodium de haut poids moléculaire, origine non animale |
| Concentration d’AH | 20 mg/mL (60 mg par seringue) |
| Technologie | NASHA® (acide hyaluronique stabilisé) |
| Injections par cycle | 1 (dose unique) |
| Demi-vie articulaire | ≈ 32 jours dans le genou |
| Stéroïde | Aucun |
| Aiguille recommandée | 18G à 22G (non incluse) |
| Conservation | 0 °C à 30 °C, protéger du gel |
| Durée de conservation | 36 mois |
| Statut | Ordonnance requise |
Side effects and safety
The most common reactions are temporary pain, swelling or stiffness in the treated joint, mild to moderate, resolving within a few days. Marked inflammatory reactions are uncommon. Seek care promptly for severe pain, spreading redness or fever.
After the injection
Go easy on the joint for the two days after the injection, avoiding strenuous effort and heavy loads. The lubricating effect builds over two to four weeks and can last several months.